Across TCGA patient cohorts, H1-5 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H1-5-associated genes across cancer lineages are Caspase-7-cleavedD198, ACC_pS79, and TIGAR. Each is linked with H1-5 in more than 3 cancer types. Because this analysis shows association rather than direction, both H1-5-to-partner and partner-to-H1-5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-5→partner) and Y-score (partner→H1-5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.832	+3.189	.002	.010	3	4
UCEC	ACC_pS79 →	+0.384	+2.999	.017	.035	3	2
UCEC	TIGAR →	+0.144	+3.169	.042	.019	3	2
CESC	Src_pY416 →	+0.536	+3.000	.027	.033	3	1
CESC	Src →	-0.327	-2.999	.006	.031	3	1
CESC	Caveolin-1 →	-0.835	-3.000	.012	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

H1-5 survival (RNA) · tumor vs normal (RNA) · all H1-5 data types