H1-4

Across TCGA pan-cancer cohorts, H1-4 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated H1-4 data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher H1-4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated H1-4 expression acts as an unfavorable survival marker.

LUAD, THCA, and DLBC are the cancer types where H1-4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.153	0.714	<.001	36	view →
THCA	DFS	Median	All	0.077	0.811	<.001	18	view →
DLBC	DFS	Median	IV	0.120	0.683	.001	12	view →
BLCA	DFS	Median	III,IV	0.122	0.572	.004	12	view →
LGG	DFS	Median	All	0.142	0.738	<.001	6	view →
COAD	DFS	Median	All	0.176	0.522	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

H1-4–LUAD (OS)

Open the LUAD breakdown →