H1-4

Across TCGA pan-cancer cohorts, H1-4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated H1-4 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher H1-4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated H1-4 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

CCRCC, LUAD, and GBM are the cancer types where H1-4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	IV	0.785	0.123	.009	19	view →
LUAD	OS	Tertile	III,IV	0.334	0.867	.004	10	view →
GBM	OS	Quartile	All	0.914	0.726	.026	3	view →
PDAC	DFS	Median	All	0.343	0.477	.031	2	view →
HNSC	DFS	Median	III,IV	1.000	0.937	.035	1	view →
LSCC	DFS	Quartile	All	0.909	1.000	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

H1-4–CCRCC (OS)

Open the CCRCC breakdown →