Across TCGA patient cohorts, H1-2 protein abundance is significantly associated with the RNA expression of many other genes, with 9,254 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible H1-2-associated genes across cancer lineages are TRIM24, IRAK3, and NAPEPLD. Each is linked with H1-2 in more than 3 cancer types. Because this analysis shows association rather than direction, both H1-2-to-partner and partner-to-H1-2 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-2→partner) and Y-score (partner→H1-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TRIM24 →	-0.471	-0.415	<.001	<.001	3	4
LSCC	IRAK3 →	+0.774	+0.510	.001	.002	3	4
UCEC	NAPEPLD →	-0.520	-0.560	<.001	<.001	3	3
LSCC	ZNF680 →	-0.520	-0.363	.003	.007	3	3
BRCA	GALNT16 →	+0.833	+0.661	.001	.002	3	3
HNSC	TBC1D27P →	+0.378	+0.336	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,254 associations by consensus.

Exploration

H1-2 survival (RNA) · tumor vs normal (RNA) · all H1-2 data types