Across TCGA patient cohorts, H1-2 mutation is significantly associated with the RNA expression of many other genes, with 300 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible H1-2-associated genes across cancer lineages are RNA5SP152, EIF4E2P2, and H2AB3. Each is linked with H1-2 in more than 2 cancer types. Because this analysis shows association rather than direction, both H1-2-to-partner and partner-to-H1-2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-2→partner) and Y-score (partner→H1-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP152 →	+0.338	+2.368	.003	.007	3	3
DLBC	EIF4E2P2 →	+0.154	+3.078	.005	.008	3	2
DLBC	H2AB3 →	+0.115	+3.426	<.001	.004	3	2
LIHC	PRKCE-AS1 →	+0.081	+4.853	<.001	<.001	3	2
LIHC	RN7SL65P →	+0.057	+4.293	.003	.009	3	2
SKCM	MTND1P33 →	+0.051	+5.624	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 300 associations by consensus.

Exploration

H1-2 survival (RNA) · tumor vs normal (RNA) · all H1-2 data types