Across TCGA patient cohorts, H1-2 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible H1-2-associated genes across cancer lineages are CD8+ Tem, Macrophages M1, and NKT. Each is linked with H1-2 in more than 1 cancer types. Because this analysis shows association rather than direction, both H1-2-to-partner and partner-to-H1-2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-2→partner) and Y-score (partner→H1-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	CD8+ Tem →	+0.016	+5.285	<.001	.049	3	1
LUSC	Macrophages M1 →	-0.031	-3.125	.020	.019	3	1
LUSC	NKT →	+0.070	+3.333	.030	.005	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Exploration

H1-2 survival (RNA) · tumor vs normal (RNA) · all H1-2 data types