Across TCGA cell cohorts, H1-2 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible H1-2-associated genes across cancer lineages are CD80, PLVAP, and KLHDC7B. Each is linked with H1-2 in more than 1 cancer types. Because this analysis shows association rather than direction, both H1-2-to-partner and partner-to-H1-2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-2→partner) and Y-score (partner→H1-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CD80 →	+0.043	+3.648	.008	.002	3	1
LARGE_INTESTINE	PLVAP →	+0.251	+3.539	<.001	.004	3	1
LARGE_INTESTINE	KLHDC7B →	+0.554	+3.444	.001	.003	3	1
LARGE_INTESTINE	ECE2 →	+0.246	+2.791	<.001	.005	3	1
LARGE_INTESTINE	SFRP2 →	+0.069	+2.716	.003	.009	3	1
LARGE_INTESTINE	PMP2 →	+0.106	+3.708	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Exploration

H1-2 survival (RNA) · tumor vs normal (RNA) · all H1-2 data types