Across TCGA pan-cancer cohorts, H1-10 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated H1-10 data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher H1-10 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated H1-10 expression acts as an unfavorable survival marker.

OV, UCEC, and ESCA are the cancer types where H1-10 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.170	0.844	<.001	42	view →
UCEC	OS	Median	II,III,IV	0.231	0.768	.010	24	view →
ESCA	OS	Median	II,III,IV	0.321	0.685	.035	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: H1-10 tumor-vs-normal RNA expression · all H1-10 data types