Across TCGA pan-cancer cohorts, GZMM Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated GZMM data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher GZMM Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GZMM expression acts as an unfavorable survival marker.

LUSC, UCEC, and LUAD are the cancer types where GZMM Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	III,IV	0.147	0.664	.028	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUAD	DFS	Median	All	0.244	0.791	.007	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: GZMM tumor-vs-normal RNA expression · all GZMM data types