GZMK

Across TCGA patient cohorts, GZMK protein abundance is significantly associated with the RNA expression of many other genes, with 11,305 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GZMK-associated genes across cancer lineages are LY9, FCRL3, and SP140. Each is linked with GZMK in more than 8 cancer types. Because this analysis shows association rather than direction, both GZMK-to-partner and partner-to-GZMK results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GZMK versus LY9 in LSCC, with a Pearson correlation of 0.67.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GZMK→partner) and Y-score (partner→GZMK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LY9 →	+0.860	+0.729	<.001	<.001	3	9
BRCA	FCRL3 →	+1.407	+1.163	<.001	<.001	3	9
BRCA	SP140 →	+1.251	+0.962	<.001	.005	3	9
BRCA	IL2RB →	+1.911	+1.188	<.001	<.001	3	8
BRCA	SLA2 →	+1.497	+1.196	<.001	<.001	3	8
BRCA	MAP4K1 →	+1.480	+1.206	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,305 associations by consensus.

GZMK vs LY9 — LSCC

Explore this scatter interactively →