GZMK

Across TCGA patient cohorts, GZMK mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GZMK-associated genes across cancer lineages are ASNS, EGFR_pY1068, and eIF4E. Each is linked with GZMK in more than 1 cancer types. Because this analysis shows association rather than direction, both GZMK-to-partner and partner-to-GZMK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by GZMK-low versus GZMK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GZMK→partner) and Y-score (partner→GZMK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.470	+2.321	.003	.034	3	2
UCEC	EGFR_pY1068 →	-0.259	-2.700	.022	.006	3	1
UCEC	eIF4E →	+0.187	+3.169	.049	.019	3	1
UCEC	FASN →	+0.376	+2.000	.034	.032	3	1
UCEC	FoxM1 →	+0.254	+2.000	.029	.032	3	1
UCEC	MEK1 →	+0.387	+2.700	.018	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

ASNS by GZMK expression — UCEC

Explore this box plot interactively →