GZMK

Across TCGA cell cohorts, GZMK RNA expression is significantly associated with the go_rna of many other GO terms, with 594 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GZMK-associated GO terms across cancer lineages are Protein processing, Regulation of wound healing, spreading of epidermal cells, and Regulation of NMDA receptor activity. Each is linked with GZMK in more than 2 cancer types. Because this analysis shows association rather than direction, both GZMK-to-partner and partner-to-GZMK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein processing grouped by GZMK-low versus GZMK-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GZMK→partner) and Y-score (partner→GZMK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Protein processing →	-0.069	-0.286	<.001	.003	3	2
BLOOD_Leukemia	Regulation of wound healing, spreading of epidermal cells →	-0.101	-0.231	<.001	.006	3	2
BLOOD_Leukemia	Regulation of NMDA receptor activity →	-0.997	-0.211	<.001	.002	3	2
BLOOD_Leukemia	Regulation of nucleotide-excision repair →	+0.094	+0.284	<.001	.005	3	2
BLOOD_Leukemia	Eosinophil mediated immunity →	+0.157	+0.251	<.001	.007	3	2
BLOOD_Leukemia	Regulation of chromosome organization →	+0.049	+0.270	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 594 associations by consensus.

Protein processing by GZMK expression — BLOOD_Leukemia

Explore this box plot interactively →