GZMK

Across TCGA cell cohorts, GZMK mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible GZMK-associated genes across cancer lineages are OR1L6, OR13C8, and ACER1. Each is linked with GZMK in more than 1 cancer types. Because this analysis shows association rather than direction, both GZMK-to-partner and partner-to-GZMK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L6 grouped by GZMK-low versus GZMK-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GZMK→partner) and Y-score (partner→GZMK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR1L6 →	+0.014	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR13C8 →	+0.024	+4.662	<.001	.005	3	1
LARGE_INTESTINE	ACER1 →	+0.103	+3.823	<.001	.006	3	1
LARGE_INTESTINE	GALP →	+0.016	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OR1L6 by GZMK expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →