GZMB

Across TCGA pan-cancer cohorts, GZMB Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated GZMB data layer compared with 28 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher GZMB Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated GZMB expression acts as an unfavorable survival marker.

LUAD, LUSC, and LIHC are the cancer types where GZMB Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	II,III,IV	0.134	0.684	<.001	29	view →
LUSC	OS	Median	All	0.002	0.776	<.001	24	view →
LIHC	DFS	Median	II,III,IV	0.079	0.429	.005	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

GZMB–LUAD (DFS)

Open the LUAD breakdown →