GZMB

Across TCGA patient cohorts, GZMB RNA expression is significantly associated with the protein abundance of many other proteins, with 16,076 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible GZMB-associated proteins across cancer lineages are ITGAL, LCP2, and GIMAP7. Each is linked with GZMB in more than 9 cancer types. Because this analysis shows association rather than direction, both GZMB-to-partner and partner-to-GZMB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GZMB versus ITGAL in BRCA, with a Pearson correlation of 0.72.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GZMB→partner) and Y-score (partner→GZMB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ITGAL →	+0.758	+1.779	<.001	<.001	3	10
BRCA	LCP2 →	+0.522	+2.004	<.001	<.001	3	10
BRCA	GIMAP7 →	+0.680	+1.643	<.001	<.001	3	10
HNSC	GIMAP8 →	+0.651	+1.571	<.001	<.001	3	10
HNSC	STK10 →	+0.383	+1.276	<.001	<.001	3	9
HNSC	WARS1 →	+0.862	+1.324	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,076 associations by consensus.

GZMB vs ITGAL — BRCA

Explore this scatter interactively →