GZMB

Across TCGA patient cohorts, GZMB protein abundance is significantly associated with the RNA expression of many other genes, with 7,590 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GZMB-associated genes across cancer lineages are IL2RB, LILRB1, and CRTAM. Each is linked with GZMB in more than 4 cancer types. Because this analysis shows association rather than direction, both GZMB-to-partner and partner-to-GZMB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GZMB versus IL2RB in BRCA, with a Pearson correlation of 0.58.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GZMB→partner) and Y-score (partner→GZMB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IL2RB →	+1.431	+0.893	<.001	<.001	3	5
UCEC	LILRB1 →	+1.159	+0.756	.005	.001	3	5
UCEC	CRTAM →	+1.302	+0.656	<.001	.008	3	5
UCEC	IFNG →	+1.496	+0.841	<.001	<.001	3	5
UCEC	FASLG →	+1.731	+0.752	<.001	.005	3	5
HNSC	CD274 →	+1.535	+1.092	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,590 associations by consensus.

GZMB vs IL2RB — BRCA

Explore this scatter interactively →