GZMB

Across TCGA patient cohorts, GZMB protein abundance is significantly associated with the protein abundance of many other proteins, with 15,389 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GZMB-associated proteins across cancer lineages are GZMA, APOL3, and CCL5. Each is linked with GZMB in more than 4 cancer types. Because this analysis shows association rather than direction, both GZMB-to-partner and partner-to-GZMB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GZMB versus GZMA in BRCA, with a Pearson correlation of 0.63.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GZMB→partner) and Y-score (partner→GZMB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GZMA →	+0.908	+0.795	<.001	<.001	3	5
HNSC	APOL3 →	+0.944	+1.066	<.001	<.001	3	5
BRCA	CCL5 →	+0.961	+0.816	<.001	<.001	3	5
HNSC	CD48 →	+1.330	+1.308	<.001	<.001	3	5
BRCA	RCSD1_S351 →	+0.810	+1.189	<.001	<.001	3	5
HNSC	RNF213 →	+0.664	+1.115	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,389 associations by consensus.

GZMB vs GZMA — BRCA

Explore this scatter interactively →