GZMB

Across TCGA cell cohorts, GZMB RNA expression is significantly associated with the go_rna of many other GO terms, with 2,136 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GZMB-associated GO terms across cancer lineages are Negative regulation of calcium ion transport into cytosol, Neural crest formation, and Vacuole organization. Each is linked with GZMB in more than 4 cancer types. Because this analysis shows association rather than direction, both GZMB-to-partner and partner-to-GZMB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of calcium ion transport into cytosol grouped by GZMB-low versus GZMB-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GZMB→partner) and Y-score (partner→GZMB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of calcium ion transport into cytosol →	-0.177	-0.640	.006	.004	3	5
UPPER_AERODIGESTIVE_TRACT	Neural crest formation →	-0.118	-0.536	.006	.006	3	4
SKIN	Vacuole organization →	+0.033	+0.352	<.001	<.001	3	4
OESOPHAGUS	Exit from mitosis →	+0.070	+0.646	.008	.002	2	5
OESOPHAGUS	Endosomal transport →	+0.059	+0.803	.001	.004	3	4
SKIN	Cytosolic transport →	+0.064	+0.441	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,136 associations by consensus.

Negative regulation of calcium ion transport into cytosol by GZMB expression — OESOPHAGUS

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