GZMA

Across TCGA pan-cancer cohorts, GZMA mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GZMA data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher GZMA mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GZMA expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

COAD, PDAC, and CCRCC are the cancer types where GZMA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	0.912	1.000	.021	36	view →
PDAC	DFS	Median	II,III,IV	0.855	0.697	<.001	36	view →
CCRCC	DFS	Quartile	All	0.943	0.256	.001	20	view →
LUAD	DFS	Quartile	III,IV	1.000	0.434	.003	16	view →
HNSC	DFS	Quartile	All	0.886	1.000	.015	8	view →
LSCC	OS	Tertile	II,III,IV	0.563	0.828	.036	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GZMA–COAD (DFS)

Open the COAD breakdown →