GZMA

Across TCGA patient cohorts, GZMA protein abundance is significantly associated with the RNA expression of many other genes, with 13,470 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GZMA-associated genes across cancer lineages are IL2RB, NKG7, and GZMK. Each is linked with GZMA in more than 9 cancer types. Because this analysis shows association rather than direction, both GZMA-to-partner and partner-to-GZMA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GZMA versus IL2RB in GBM, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GZMA→partner) and Y-score (partner→GZMA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IL2RB →	+1.413	+1.061	<.001	.002	3	10
GBM	NKG7 →	+2.315	+1.305	<.001	<.001	3	10
OV	GZMK →	+1.564	+1.039	<.001	<.001	3	10
GBM	CYTIP →	+1.810	+1.150	<.001	<.001	3	10
GBM	CD2 →	+2.618	+1.391	<.001	.001	3	10
BRCA	SLAMF1 →	+1.129	+0.863	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,470 associations by consensus.

GZMA vs IL2RB — GBM

Explore this scatter interactively →