GZMA

Across TCGA patient cohorts, GZMA mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GZMA-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and CDK1. Each is linked with GZMA in more than 1 cancer types. Because this analysis shows association rather than direction, both GZMA-to-partner and partner-to-GZMA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by GZMA-low versus GZMA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GZMA→partner) and Y-score (partner→GZMA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.702	-3.308	<.001	.009	3	2
UCEC	Caspase-7-cleavedD198 →	+0.704	+2.242	.003	.005	3	2
UCEC	CDK1 →	+0.180	+2.598	.003	.005	3	2
COAD	p62 Lck ligand →	+0.582	+3.008	.003	.019	2	2
COAD	PREX1 →	+0.260	+3.025	.015	.019	3	1
UCEC	14-3-3_beta →	-0.094	-1.847	.020	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

ATM by GZMA expression — UCEC

Explore this box plot interactively →