GZMA

Across TCGA cell cohorts, GZMA RNA expression is significantly associated with the go_rna of many other GO terms, with 1,373 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GZMA-associated GO terms across cancer lineages are Cellular response to environmental stimulus, Cellular response to abiotic stimulus, and Negative regulation of telomere maintenance via telomerase. Each is linked with GZMA in more than 4 cancer types. Because this analysis shows association rather than direction, both GZMA-to-partner and partner-to-GZMA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to environmental stimulus grouped by GZMA-low versus GZMA-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GZMA→partner) and Y-score (partner→GZMA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Cellular response to environmental stimulus →	+0.035	+0.017	.002	.008	3	5
UPPER_AERODIGESTIVE_TRACT	Cellular response to abiotic stimulus →	+0.035	+0.017	.002	.008	3	5
BLOOD_Leukemia	Negative regulation of telomere maintenance via telomerase →	+0.059	+2.374	.001	<.001	3	4
BLOOD_Leukemia	Spliceosomal snRNP assembly →	+0.041	+1.625	.003	.005	3	4
UPPER_AERODIGESTIVE_TRACT	Regulation of amyloid fibril formation →	+0.110	+0.014	.004	.002	3	4
BLOOD_Lymphoma	Regulation of plasma membrane repair →	+0.183	+2.392	.001	.007	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,373 associations by consensus.

Cellular response to environmental stimulus by GZMA expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →