GZF1

Across TCGA patient cohorts, GZF1 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GZF1-associated genes across cancer lineages are GSK-3_pS9, Caspase-7-cleavedD198, and ERK2. Each is linked with GZF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GZF1-to-partner and partner-to-GZF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3_pS9 grouped by GZF1-low versus GZF1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GZF1→partner) and Y-score (partner→GZF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	GSK-3_pS9 →	-0.413	-3.000	.033	.036	3	2
STAD	Caspase-7-cleavedD198 →	+1.028	+3.000	.007	.036	3	2
UCEC	ERK2 →	+0.153	+1.700	.018	.040	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.381	+2.232	.025	.005	3	2
UCEC	JNK2 →	+0.234	+1.584	<.001	.009	3	2
UCEC	MEK1_p_S217_S221 →	-0.203	-1.584	.026	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

GSK-3_pS9 by GZF1 expression — STAD

Explore this box plot interactively →