GZF1

Across TCGA cell cohorts, GZF1 mutation is significantly associated with the RNA expression of many other genes, with 1,510 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GZF1-associated genes across cancer lineages are IQCF5, CD1A, and OR5J2. Each is linked with GZF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GZF1-to-partner and partner-to-GZF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by GZF1-low versus GZF1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GZF1→partner) and Y-score (partner→GZF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	IQCF5 →	+0.056	+5.357	<.001	.003	3	2
CNS	CD1A →	+0.069	+4.285	<.001	.001	3	1
CNS	OR5J2 →	+0.044	+4.772	<.001	.002	3	1
CNS	SLC22A10 →	+0.019	+3.643	.002	.007	3	1
CNS	KRTAP10-6 →	+0.030	+4.285	<.001	.001	3	1
CNS	SCYGR10 →	+0.286	+4.169	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,510 associations by consensus.

IQCF5 by GZF1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →