GYS2

Across TCGA patient cohorts, GYS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,140 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible GYS2-associated GO terms across cancer lineages are Regulation of telomere maintenance, Regulation of nucleotide-excision repair, and Positive regulation of telomere maintenance. Each is linked with GYS2 in more than 24 cancer types. Because this analysis shows association rather than direction, both GYS2-to-partner and partner-to-GYS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of telomere maintenance grouped by GYS2-low versus GYS2-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GYS2→partner) and Y-score (partner→GYS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of telomere maintenance →	+0.116	+0.225	<.001	.002	3	25
THYM	Regulation of nucleotide-excision repair →	+0.050	+0.183	<.001	<.001	3	23
STAD	Positive regulation of telomere maintenance →	+0.074	+0.145	<.001	.002	3	23
UVM	Peptidyl-lysine modification →	+0.039	+0.071	<.001	<.001	3	22
STAD	Regulation of transcription elongation by RNA polymerase II →	+0.117	+0.269	<.001	<.001	3	22
STAD	Epigenetic regulation of gene expression →	+0.067	+0.148	<.001	.001	3	22

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,140 associations by consensus.

Regulation of telomere maintenance by GYS2 expression — STAD

Explore this box plot interactively →