GYS2

Across TCGA patient cohorts, GYS2 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GYS2-associated genes across cancer lineages are PCNA, eIF4E, and MEK1. Each is linked with GYS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both GYS2-to-partner and partner-to-GYS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by GYS2-low versus GYS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GYS2→partner) and Y-score (partner→GYS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.278	+1.893	<.001	<.001	3	3
UCEC	eIF4E →	+0.207	+2.169	.001	<.001	3	2
UCEC	MEK1 →	+0.424	+2.662	<.001	<.001	3	2
UCEC	MSH2 →	-0.229	-1.739	.001	.012	3	2
UCEC	p62 Lck ligand →	+0.295	+1.893	.003	<.001	3	2
UCEC	PDCD4 →	-0.451	-2.222	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

PCNA by GYS2 expression — UCEC

Explore this box plot interactively →