GYS1

Across TCGA patient cohorts, GYS1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GYS1-associated genes across cancer lineages are JNK2, Caspase-7-cleavedD198, and ERK2. Each is linked with GYS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GYS1-to-partner and partner-to-GYS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by GYS1-low versus GYS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GYS1→partner) and Y-score (partner→GYS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.169	+1.247	.012	.045	3	2
UCEC	Caspase-7-cleavedD198 →	+0.557	+1.604	.005	.041	3	2
UCEC	ERK2 →	+0.130	+1.584	.047	.034	3	1
UCEC	MEK1 →	+0.492	+2.523	<.001	<.001	3	1
UCEC	MSH2 →	-0.263	-1.674	<.001	.040	3	1
UCEC	Notch1 →	+0.124	+1.817	.009	.015	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

JNK2 by GYS1 expression — UCEC

Explore this box plot interactively →