Across TCGA patient cohorts, GYPE mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GYPE-associated genes across cancer lineages are MSH2, Notch1, and P-Cadherin. Each is linked with GYPE in more than 1 cancer types. Because this analysis shows association rather than direction, both GYPE-to-partner and partner-to-GYPE results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GYPE→partner) and Y-score (partner→GYPE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.319	-2.459	.004	.020	3	1
UCEC	Notch1 →	+0.183	+2.817	.007	.036	3	1
UCEC	P-Cadherin →	-0.159	-2.446	.022	.020	3	1
UCEC	G6PD →	-0.353	-3.439	.024	.005	2	1
UCEC	eIF4E →	+0.222	+3.584	.029	.002	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

GYPE survival (RNA) · tumor vs normal (RNA) · all GYPE data types