Across TCGA cell cohorts, GYPE mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. CNS shows the largest number of these associations.

The most reproducible GYPE-associated genes across cancer lineages are OR5AK2, IFNA4, and GYPB. Each is linked with GYPE in more than 1 cancer types. Because this analysis shows association rather than direction, both GYPE-to-partner and partner-to-GYPE results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GYPE→partner) and Y-score (partner→GYPE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR5AK2 →	+0.016	+4.321	<.001	.009	3	1
CNS	IFNA4 →	+0.160	+4.321	<.001	.009	3	1
CNS	GYPB →	+0.073	+4.754	<.001	.005	3	1
CNS	CYP4A22 →	+0.018	+4.345	<.001	.005	1	1
CNS	TRPM5 →	+0.038	+4.297	<.001	.006	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

GYPE survival (RNA) · tumor vs normal (RNA) · all GYPE data types