GYPC

Across TCGA pan-cancer cohorts, GYPC RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated GYPC data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GYPC RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated GYPC expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, HNSC, and KIRC are the cancer types where GYPC RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.729	0.567	<.001	104	view →
HNSC	DFS	Quartile	All	0.452	0.217	<.001	75	view →
KIRC	DFS	Quartile	III,IV	0.592	0.299	<.001	60	view →
CESC	OS	Tertile	All	0.841	0.692	.006	52	view →
UVM	DFS	Median	All	0.780	0.366	<.001	49	view →
SKCM	OS	Quartile	III,IV	0.516	0.778	<.001	41	view →
LUSC	DFS	Quartile	II,III,IV	0.426	0.695	.001	40	view →
LGG	DFS	Median	All	0.312	0.491	<.001	37	view →
BLCA	DFS	Median	All	0.454	0.565	.008	24	view →
THCA	DFS	Tertile	IV	0.885	0.536	.014	17	view →
CHOL	DFS	Quartile	II,III,IV	0.806	0.146	.017	14	view →
UCS	OS	Tertile	IV	0.311	1.000	.049	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GYPC–UCEC (DFS)

Open the UCEC breakdown →