GXYLT2

Across TCGA patient cohorts, GXYLT2 mutation is significantly associated with the RNA expression of many other genes, with 1,160 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GXYLT2-associated genes across cancer lineages are VTI1B, RPS15AP3, and RWDD1. Each is linked with GXYLT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both GXYLT2-to-partner and partner-to-GXYLT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VTI1B grouped by GXYLT2-low versus GXYLT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GXYLT2→partner) and Y-score (partner→GXYLT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VTI1B →	+0.399	+2.807	.007	.003	3	3
LUSC	RPS15AP3 →	+0.083	+3.536	.008	.004	3	3
UCEC	RWDD1 →	+0.548	+2.893	<.001	.001	3	2
UCEC	EBNA1BP2 →	+0.535	+3.917	.007	<.001	3	2
UCEC	ITGB1BP1 →	+0.391	+2.828	.007	.001	3	2
UCEC	TCP1 →	+0.587	+2.601	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,160 associations by consensus.

VTI1B by GXYLT2 expression — UCEC

Explore this box plot interactively →