GXYLT1

Across TCGA patient cohorts, GXYLT1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GXYLT1-associated genes across cancer lineages are ASNS, 14-3-3_beta, and EGFR_pY1068. Each is linked with GXYLT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GXYLT1-to-partner and partner-to-GXYLT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by GXYLT1-low versus GXYLT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GXYLT1→partner) and Y-score (partner→GXYLT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.428	+1.415	.001	.046	3	2
UCEC	14-3-3_beta →	-0.109	-2.673	.003	.005	3	1
UCEC	EGFR_pY1068 →	-0.240	-1.700	.010	.042	3	1
UCEC	A-Raf_pS299 →	-0.128	-3.169	.004	.018	3	1
UCEC	G6PD →	-0.285	-3.156	.018	.018	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.564	+2.169	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

ASNS by GXYLT1 expression — UCEC

Explore this box plot interactively →