GUSBP3

Across TCGA pan-cancer cohorts, GUSBP3 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated GUSBP3 data layer compared with 1 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GUSBP3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GUSBP3 expression acts as an unfavorable survival marker, although some lineages such as UVM and KIRC show a favorable association.

UCEC, KICH, and UVM are the cancer types where GUSBP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.376	0.681	<.001	106	view →
KICH	DFS	Tertile	III,IV	0.142	1.000	<.001	76	view →
UVM	DFS	Tertile	III,IV	0.992	0.535	.015	37	view →
LUAD	DFS	Tertile	IV	0.364	0.817	.001	37	view →
LIHC	DFS	Median	All	0.349	0.508	<.001	34	view →
LUSC	OS	Tertile	IV	0.001	0.651	.025	18	view →
KIRC	DFS	Tertile	IV	0.646	0.255	.015	16	view →
READ	DFS	Median	All	0.678	0.286	.014	16	view →
STAD	DFS	Median	III,IV	0.470	0.705	.009	15	view →
CESC	OS	Median	All	0.731	0.421	.011	10	view →
GBM	DFS	Tertile	All	0.277	0.131	.003	9	view →
SKCM	DFS	Tertile	IV	0.059	0.531	.004	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GUSBP3–UCEC (OS)

Open the UCEC breakdown →