GUSBP2

Across TCGA patient cohorts, GUSBP2 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GUSBP2-associated genes across cancer lineages are ACC_pS79, ACC1, and MEK1. Each is linked with GUSBP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GUSBP2-to-partner and partner-to-GUSBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC_pS79 grouped by GUSBP2-low versus GUSBP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUSBP2→partner) and Y-score (partner→GUSBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC_pS79 →	+0.428	+2.817	.024	.036	3	1
UCEC	ACC1 →	+0.427	+3.000	.032	.036	3	1
UCEC	MEK1 →	+0.455	+3.169	.023	.020	1	1
UCEC	p62 Lck ligand →	+0.455	+3.169	.010	.020	1	1
UCEC	VHL →	-1.371	-3.169	<.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ACC_pS79 by GUSBP2 expression — UCEC

Explore this box plot interactively →