GUSB

Across TCGA pan-cancer cohorts, GUSB mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of GUSB’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where GUSB mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types GUSB is over-expressed in tumor, although a few such as CCRCC and LSCC show the opposite, repressed pattern.

CCRCC, LUAD, and PDAC are the cancer types where GUSB tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GUSB mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	III,IV	−0.620	<.001	12	view →
LUAD	All	III,IV	+0.406	<.001	9	view →
PDAC	All	All	+0.584	<.001	6	view →
LSCC	All	II,III,IV	−0.178	<.001	4	view →
COAD	All	All	−0.206	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

GUSB–CCRCC

Open the CCRCC breakdown →