GUSB

Across TCGA patient cohorts, GUSB mutation is significantly associated with the RNA expression of many other genes, with 3,076 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GUSB-associated genes across cancer lineages are RNU6-13P, RNU6-362P, and LINC01808. Each is linked with GUSB in more than 2 cancer types. Because this analysis shows association rather than direction, both GUSB-to-partner and partner-to-GUSB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-13P grouped by GUSB-low versus GUSB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUSB→partner) and Y-score (partner→GUSB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-13P →	+0.251	+2.137	<.001	.001	3	3
LUSC	RNU6-362P →	+0.282	+5.906	<.001	.001	3	3
LIHC	LINC01808 →	+0.152	+4.690	<.001	.003	3	2
UCEC	MAP3K4-AS1 →	+0.707	+2.510	<.001	.001	3	2
UCEC	DCP1A →	+0.452	+2.930	.003	<.001	3	2
UCEC	TUBGCP5 →	+0.409	+2.169	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,076 associations by consensus.

RNU6-13P by GUSB expression — UCEC

Explore this box plot interactively →