GUSB

Across TCGA patient cohorts, GUSB mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GUSB-associated genes across cancer lineages are Annexin-1, ASNS, and eIF4E. Each is linked with GUSB in more than 1 cancer types. Because this analysis shows association rather than direction, both GUSB-to-partner and partner-to-GUSB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by GUSB-low versus GUSB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUSB→partner) and Y-score (partner→GUSB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.595	+2.000	.002	.029	3	2
UCEC	ASNS →	+0.412	+1.700	.002	.042	3	2
UCEC	eIF4E →	+0.161	+2.169	.041	.003	3	1
UCEC	JNK2 →	+0.215	+3.486	.003	.002	3	1
UCEC	MEK1 →	+0.368	+2.662	.007	<.001	3	1
UCEC	Notch1 →	+0.124	+1.594	.019	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Annexin-1 by GUSB expression — UCEC

Explore this box plot interactively →