GUSB

Across TCGA cell cohorts, GUSB RNA expression is significantly associated with the go_rna of many other GO terms, with 3,206 significant associations in total. CNS shows the largest number of these associations.

The most reproducible GUSB-associated GO terms across cancer lineages are Chondroitin sulfate proteoglycan catabolic process, Pre-mRNA catabolic process, and Actomyosin contractile ring organization. Each is linked with GUSB in more than 12 cancer types. Because this analysis shows association rather than direction, both GUSB-to-partner and partner-to-GUSB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chondroitin sulfate proteoglycan catabolic process grouped by GUSB-low versus GUSB-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GUSB→partner) and Y-score (partner→GUSB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Chondroitin sulfate proteoglycan catabolic process →	+0.213	+1.327	<.001	<.001	3	13
BLOOD_Lymphoma	Pre-mRNA catabolic process →	+0.121	+1.040	<.001	<.001	3	10
BONE	Actomyosin contractile ring organization →	+0.206	+1.138	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Cell division →	+0.050	+0.555	<.001	.006	3	9
UPPER_AERODIGESTIVE_TRACT	Protein targeting to lysosome →	+0.105	+1.202	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Cytosolic transport →	+0.069	+0.857	.002	.006	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,206 associations by consensus.

Chondroitin sulfate proteoglycan catabolic process by GUSB expression — BLOOD_Myeloma

Explore this box plot interactively →