GUSB

Across TCGA cell cohorts, GUSB mutation is significantly associated with the RNA expression of many other genes, with 117 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GUSB-associated genes across cancer lineages are ACER1, SLC32A1, and SV2C. Each is linked with GUSB in more than 2 cancer types. Because this analysis shows association rather than direction, both GUSB-to-partner and partner-to-GUSB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACER1 grouped by GUSB-low versus GUSB-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUSB→partner) and Y-score (partner→GUSB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ACER1 →	+0.324	+3.672	<.001	.003	3	3
URINARY_TRACT	SLC32A1 →	+0.012	+4.087	<.001	.009	3	2
BLOOD_Leukemia	SV2C →	+0.277	+2.956	<.001	.008	3	2
URINARY_TRACT	ACOD1 →	+0.040	+4.217	<.001	.005	3	1
URINARY_TRACT	LCN1 →	+0.037	+4.217	<.001	.005	3	1
URINARY_TRACT	MPC1L →	+0.062	+4.087	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 117 associations by consensus.

ACER1 by GUSB expression — BLOOD_Leukemia

Explore this box plot interactively →