GULP1

Across TCGA patient cohorts, GULP1 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GULP1-associated genes across cancer lineages are EGFR, eIF4E, and A-Raf_pS299. Each is linked with GULP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GULP1-to-partner and partner-to-GULP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by GULP1-low versus GULP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GULP1→partner) and Y-score (partner→GULP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.147	-1.848	.009	.049	3	1
UCEC	eIF4E →	+0.182	+3.472	.014	.002	3	1
UCEC	A-Raf_pS299 →	-0.118	-1.700	.004	.042	3	1
UCEC	ERK2 →	+0.153	+1.362	.024	.037	3	1
UCEC	FASN →	+0.358	+1.362	.010	.037	3	1
UCEC	ACC_pS79 →	+0.354	+2.459	.003	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

EGFR by GULP1 expression — UCEC

Explore this box plot interactively →