GUF1

Across TCGA pan-cancer cohorts, GUF1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GUF1 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher GUF1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated GUF1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where GUF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	1.000	0.796	.001	38	view →
PDAC	OS	Quartile	III,IV	0.835	0.371	.011	10	view →
LUAD	DFS	Quartile	III,IV	0.875	0.333	.007	9	view →
HNSC	OS	Median	All	0.339	0.891	.020	4	view →
LSCC	OS	Median	II,III,IV	1.000	0.882	.020	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GUF1–CCRCC (OS)

Open the CCRCC breakdown →