GUF1

Across TCGA patient cohorts, GUF1 mutation is significantly associated with the RNA expression of many other genes, with 2,515 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GUF1-associated genes across cancer lineages are RNA5SP73, H3Y2, and OR2G6. Each is linked with GUF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GUF1-to-partner and partner-to-GUF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP73 grouped by GUF1-low versus GUF1-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUF1→partner) and Y-score (partner→GUF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RNA5SP73 →	+0.550	+5.647	<.001	.004	3	2
LIHC	H3Y2 →	+0.904	+5.186	<.001	.007	3	2
LIHC	OR2G6 →	+0.055	+5.447	<.001	.005	3	2
LIHC	RNU4-85P →	+0.374	+5.544	<.001	.004	3	2
LIHC	RN7SL813P →	+0.181	+5.447	<.001	.005	3	2
BLCA	RNU6-225P →	+0.352	+7.640	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,515 associations by consensus.

RNA5SP73 by GUF1 expression — LIHC

Explore this box plot interactively →