GUF1

Across TCGA patient cohorts, GUF1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GUF1-associated genes across cancer lineages are mTOR_pS2448, Rab25, and Caspase-7-cleavedD198. Each is linked with GUF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GUF1-to-partner and partner-to-GUF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by GUF1-low versus GUF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUF1→partner) and Y-score (partner→GUF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.114	-1.986	.029	.029	3	2
UCEC	Rab25 →	-0.524	-3.087	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.667	+2.107	.001	.002	3	2
UCEC	53BP1 →	+0.296	+2.459	.014	.018	3	2
COAD	Lck →	+0.393	+2.832	.019	.035	3	2
UCEC	14-3-3_beta →	-0.104	-3.673	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

mTOR_pS2448 by GUF1 expression — UCEC

Explore this box plot interactively →