GUCY2GP

Across TCGA pan-cancer cohorts, GUCY2GP RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of GUCY2GP’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GUCY2GP RNA is repressed in tumor relative to normal tissue. In most cancer types GUCY2GP is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, LUAD, and LIHC are the cancer types where GUCY2GP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GUCY2GP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	III,IV	−0.026	<.001	10	view →
LUAD	All	All	+0.031	.003	3	view →
LIHC	All	All	+0.013	.007	3	view →
KICH	All	All	−0.058	.016	2	view →
KIRP	Male	All	−0.030	.004	2	view →
BRCA	All	III,IV	−0.020	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

GUCY2GP–KIRC

Open the KIRC breakdown →