GUCY2F

Across TCGA patient cohorts, GUCY2F mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GUCY2F-associated genes across cancer lineages are Cyclin-B1, MYH11, and PCNA. Each is linked with GUCY2F in more than 3 cancer types. Because this analysis shows association rather than direction, both GUCY2F-to-partner and partner-to-GUCY2F results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by GUCY2F-low versus GUCY2F-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCY2F→partner) and Y-score (partner→GUCY2F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.598	+2.263	<.001	<.001	3	4
LUAD	MYH11 →	-1.106	-3.000	.004	.035	3	3
UCEC	PCNA →	+0.151	+1.415	.010	.008	3	3
SKCM	ASNS →	+0.362	+2.000	.017	.029	3	3
LUAD	EGFR_pY1068 →	-0.422	-3.000	.047	.034	3	2
UCEC	A-Raf_pS299 →	-0.107	-1.523	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Cyclin-B1 by GUCY2F expression — UCEC

Explore this box plot interactively →