GUCY2F

Across TCGA cell cohorts, GUCY2F mutation is significantly associated with the RNA expression of many other genes, with 204 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GUCY2F-associated genes across cancer lineages are FAM86B2, FAM86B1, and GML. Each is linked with GUCY2F in more than 1 cancer types. Because this analysis shows association rather than direction, both GUCY2F-to-partner and partner-to-GUCY2F results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM86B2 grouped by GUCY2F-low versus GUCY2F-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCY2F→partner) and Y-score (partner→GUCY2F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM86B2 →	+0.783	+3.502	.001	.001	3	2
LARGE_INTESTINE	FAM86B1 →	+1.050	+3.502	.001	.001	3	2
BLOOD_Leukemia	GML →	+0.080	+4.152	<.001	.009	3	1
BLOOD_Leukemia	CALHM4 →	+0.019	+5.269	.004	<.001	3	1
BLOOD_Leukemia	NKX2-6 →	+0.489	+5.786	<.001	<.001	3	1
BLOOD_Leukemia	OR1G1 →	+0.083	+4.705	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 204 associations by consensus.

FAM86B2 by GUCY2F expression — LARGE_INTESTINE

Explore this box plot interactively →