GUCY1B2

Across TCGA patient cohorts, GUCY1B2 mutation is significantly associated with the RNA expression of many other genes, with 1,412 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GUCY1B2-associated genes across cancer lineages are SNORD116-3, RNA5SP412, and LYZL1. Each is linked with GUCY1B2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GUCY1B2-to-partner and partner-to-GUCY1B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD116-3 grouped by GUCY1B2-low versus GUCY1B2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCY1B2→partner) and Y-score (partner→GUCY1B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	SNORD116-3 →	+0.722	+5.103	<.001	.008	3	2
UCEC	RNA5SP412 →	+0.485	+1.967	.001	.005	3	2
CESC	LYZL1 →	+0.056	+5.418	<.001	.005	3	1
CESC	NPBWR2 →	+0.043	+5.010	<.001	.009	3	1
CESC	RN7SKP171 →	+0.216	+8.174	<.001	<.001	3	1
CESC	SNORD116-12 →	+0.569	+5.969	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,412 associations by consensus.

SNORD116-3 by GUCY1B2 expression — CESC

Explore this box plot interactively →