GUCY1B2

Across TCGA patient cohorts, GUCY1B2 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GUCY1B2-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and A-Raf_pS299. Each is linked with GUCY1B2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GUCY1B2-to-partner and partner-to-GUCY1B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by GUCY1B2-low versus GUCY1B2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCY1B2→partner) and Y-score (partner→GUCY1B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.304	-2.087	.001	.005	3	1
UCEC	eIF4E →	+0.181	+2.115	.025	.017	3	1
UCEC	A-Raf_pS299 →	-0.141	-3.169	.002	.018	3	1
UCEC	ERK2 →	+0.173	+2.584	.019	.001	3	1
UCEC	JNK2 →	+0.222	+3.469	.003	.002	3	1
UCEC	Lck →	+0.228	+2.459	.003	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

EGFR_pY1068 by GUCY1B2 expression — UCEC

Explore this box plot interactively →