GUCY1A2

Across TCGA patient cohorts, GUCY1A2 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GUCY1A2-associated genes across cancer lineages are Caspase-7-cleavedD198, JNK_pT183_Y185, and Shc_pY317. Each is linked with GUCY1A2 in more than 3 cancer types. Because this analysis shows association rather than direction, both GUCY1A2-to-partner and partner-to-GUCY1A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by GUCY1A2-low versus GUCY1A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCY1A2→partner) and Y-score (partner→GUCY1A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.556	+1.604	.005	.021	3	4
UCEC	JNK_pT183_Y185 →	-0.146	-1.700	.011	.042	3	3
UCEC	Shc_pY317 →	-0.113	-1.906	.029	.015	3	3
UCEC	4E-BP1 →	+0.218	+3.169	.018	.018	3	3
UCEC	ERK2 →	+0.157	+1.807	.016	.025	3	2
UCEC	Annexin-1 →	+0.793	+2.523	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Caspase-7-cleavedD198 by GUCY1A2 expression — UCEC

Explore this box plot interactively →