GUCY1A1

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, GUCY1A1 protein abundance is significantly associated with the RNA expression of many other genes, with 14,943 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GUCY1A1-associated genes across cancer lineages are GUCY1B1, CLEC1A, and EMCN. Each is linked with GUCY1A1 in more than 9 cancer types. Because this analysis shows association rather than direction, both GUCY1A1-to-partner and partner-to-GUCY1A1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GUCY1A1 versus GUCY1B1 in GBM, with a Pearson correlation of 0.67.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCY1A1→partner) and Y-score (partner→GUCY1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMGUCY1B1 →+0.894+0.497<.001<.001310
CCRCCCLEC1A →+0.749+0.395<.001<.00139
UCECEMCN →+1.235+0.539<.001<.00139
GBMRCAN2 →+1.554+0.487<.001<.00139
OVPRKG1 →+0.916+0.641<.001<.00139
COADGIMAP1 →+0.553+0.540<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 14,943 associations by consensus.

GUCY1A1 vs GUCY1B1 — GBM

Per-sample scatter of GUCY1A1 vs GUCY1B1 in GBM (Pearson r = 0.67).

Explore this scatter interactively →

Exploration